Surescripts routes the prescription. EPCS infrastructure authorizes controlled substance signing. PDMPs track what has already been dispensed. Each layer has its own standards, certification requirements, and regulatory obligations — and all three must work together for a complete prescribing platform.
The dominant U.S. electronic prescribing network, connecting prescribers to 67,000+ pharmacies. It routes new prescriptions, renewals, cancellations, and changes, and enables medication history and real-time benefit checking. Connecting requires application certification and NCPDP SCRIPT compliance.
Electronic Prescribing of Controlled Substances lets opioids, benzodiazepines, stimulants, and other scheduled drugs be prescribed electronically using DEA-compliant identity-proofed credentials and two-factor authentication. Most U.S. states now mandate EPCS, making it essential for any prescribing platform.
State-operated databases tracking dispensed controlled substances. Clinicians query the PDMP during prescribing to review a patient's history across state pharmacies and, via PMP InterConnect, across participating states. In mandatory-check states, the query must complete before a prescription is finalized.
ePrescription integration spans Surescripts routing, controlled substance prescribing under DEA regulations, PDMP connectivity, medication history, and real-time benefit checking — each with its own certification and compliance requirements.
We build pharmacy and ePrescription integration for EHR platforms, telehealth companies, pharmacy benefit systems, and digital health teams entering the Canadian market. Hover a card to see how we work with each.
Your prescribing workflow needs Surescripts connectivity, EPCS for controlled substances, and PDMP integration for state check mandates. We build the full stack — Surescripts certification, NCPDP SCRIPT implementation, DEA EPCS compliance, and PDMP query automation.
Clinicians prescribe at the end of every virtual visit — and that prescription needs to reach the patient's pharmacy electronically, meet DEA EPCS requirements, and pass PDMP checks inside the workflow. We build the ePrescribing infrastructure that keeps pharmacy connectivity transparent to the clinician.
On the receiving end of electronic prescriptions, you need bidirectional Surescripts connectivity for new prescriptions, renewals, and change requests, plus real-time benefit check to surface coverage and cost. We build the NCPDP SCRIPT integration for the full dispensing-side message lifecycle.
Provincial networks in BC, Alberta, and Ontario hold comprehensive prescription and dispensing history — BC's PharmaNet among the most complete medication datasets available. We navigate the provincial access process — data access agreements, technical integration, and governance — for your target market.
Five steps from Surescripts application to production launch. EPCS and PDMP compliance must be addressed in the design phase — retrofitting it later adds significant time and cost.
Register as a Surescripts partner and submit an application covering your platform, use case, and workflows. Approval grants test environment access — the prerequisite for all ePrescribing work.
Implement NCPDP SCRIPT message formats for new prescriptions, renewals, cancellations, and fill-status notifications using RxNorm codes and correct DEA/NPI identifiers, validated against the Surescripts certification test suite.
Prescribers complete identity proofing through a DEA-approved credential service provider. The application adds two-factor authentication and audit logging per 21 CFR Part 1311, then passes a third-party audit before EPCS goes live.
Connect via the state PDMP API or PMP InterConnect for multi-state access. The integration auto-queries the PDMP when a controlled substance is prescribed and surfaces the response inline. In mandatory-check states, the workflow blocks without a successful query.
Surescripts validates handling of all required scenarios — new prescriptions, renewals, cancellations, and error conditions. Once certified, the application routes prescriptions in production, with ongoing monitoring for NCPDP SCRIPT version updates.
Every protocol is implemented directly — NCPDP SCRIPT for prescription routing, DEA EPCS regulations for controlled substances, PDMP and PMP InterConnect for monitoring, and provincial APIs for the Canadian market.
The messaging standard for electronic prescriptions in the United States, required by Surescripts for all prescription routing on its network.
Surescripts services beyond prescription routing — medication history, real-time benefit check, and prior authorization.
Federal requirements governing electronic prescribing of controlled substances — identity proofing, authentication, audit logging, and application certification.
State PDMP connectivity and interstate data sharing frameworks for controlled substance prescription monitoring.
EHR and prescribing systems deployed across U.S. outpatient environments that require Surescripts and EPCS connectivity.
Provincial pharmacy systems providing prescription and dispensing data for patients within each province.
Surescripts certification, EPCS compliance, PDMP connectivity, or Canadian provincial access — we build the pharmacy integration layer that routes prescriptions correctly. Book a consultation to map your production-ready ePrescription integration.
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NCPDP SCRIPT is the messaging standard from the National Council for Prescription Drug Programs that defines the format for electronic prescriptions between U.S. prescribing and pharmacy systems. Surescripts uses it for all routing, and every U.S. EHR with ePrescribing implements it — with message types for new prescriptions, renewals, cancellations, and fill-status notifications.
The DEA's EPCS regulations (21 CFR Part 1311) require identity proofing of each prescriber through a DEA-approved credential service provider, two-factor authentication for every signing event, audit logging, and logical access controls. Before production use, the application must be certified by a DEA-approved third-party auditor.
Each U.S. state runs its own PDMP database, which once meant querying every state separately for patients who filled prescriptions across state lines. Interstate sharing is now standardized through the PMP InterConnect network, so a single integration can retrieve multi-state controlled substance history in one query instead of connecting to each state individually.
Canada has no single national ePrescribing network — it is regulated province by province, with wide variation. BC's PharmaNet is among the most mature, with a central repository of prescription and dispensing data; Alberta uses NetRx; and Ontario builds through Ontario Health. Serving the Canadian market means a multi-province strategy with separate integration work for each.
