Surescripts — The National ePrescribing Network
The dominant U.S. ePrescribing network — linking prescribers to 67,000+ pharmacies for scripts, renewals, history and benefit checks.
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Three Systems at the Center of Pharmacy Integration
Surescripts routes prescriptions, EPCS authorizes controlled-substance signing, and PDMPs track dispensing — each with its own standards.
EPCS — Controlled Substance Prescribing Infrastructure
Lets scheduled drugs be prescribed electronically with DEA-compliant identity proofing and two-factor auth — now mandated in most U.S. states.
PDMP — State Prescription Monitoring Databases
State databases of dispensed controlled substances; clinicians query cross-state history via PMP InterConnect, often required before prescribing.
What Pharmacy and ePrescription Integration Actually Covers
ePrescription integration spans Surescripts routing, EPCS controlled-substance prescribing, PDMP connectivity, medication history and benefit checks.
Route prescriptions to 67,000+ pharmacies with bidirectional NCPDP SCRIPT messaging for new Rx, renewals and cancellations.
DEA-compliant identity proofing, two-factor auth and certified audit logging for controlled-substance prescribing.
Connect to state PDMPs so clinicians review controlled-substance history in-workflow via PMP InterConnect.
Surescripts Medication History pulls fill history from pharmacy claims and dispensing records for medication reconciliation.
Query the pharmacy plan at prescribing time for cost, prior-auth, formulary and cheaper alternatives.
Canada manages ePrescribing provincially — BC's PharmaNet, Alberta's NetRx and Ontario each differ.
Who This Is For
Pharmacy and ePrescription integration for EHRs, telehealth, PBMs, and teams entering Canada.
EHR Platforms & Prescribing Systems
The full prescribing stack: Surescripts certification, NCPDP SCRIPT, DEA EPCS, and PDMP automation.
Telehealth & Virtual Care Platforms
ePrescribing infrastructure that meets DEA EPCS and passes PDMP checks on every virtual visit.
Specialty Pharmacy & PBM Platforms
Bidirectional Surescripts connectivity plus real-time benefit check across the NCPDP SCRIPT lifecycle.
Digital Health Teams in Canada
BC, Alberta, and Ontario networks hold deep prescription history; we navigate access and governance.
The Pharmacy Integration Process
Five steps from Surescripts application to production launch — address EPCS and PDMP compliance in design, not as a costly retrofit.
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Surescripts Registration
Surescripts Registration
Register as a Surescripts partner and apply with your platform and use case to gain test environment access.
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NCPDP SCRIPT Implementation
NCPDP SCRIPT Implementation
Implement NCPDP SCRIPT messages for prescriptions, renewals, cancellations, and fill status using RxNorm and DEA/NPI codes.
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EPCS Identity Proofing & Certification
EPCS Identity Proofing & Certification
Prescribers complete identity proofing via a DEA-approved provider; the app adds 2FA and audit logging per 21 CFR Part 1311.
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PDMP Integration Configuration
PDMP Integration Configuration
Connect via state PDMP APIs or PMP InterConnect to auto-query controlled substances and surface the response inline.
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Certification Testing & Launch
Certification Testing & Launch
Surescripts validates all required scenarios; once certified, the application routes prescriptions live in production.
Standards That Pharmacy Integration Actually Runs On
Every protocol implemented directly — NCPDP SCRIPT routing, DEA EPCS, PDMP and PMP InterConnect, and Canadian provincial APIs.
NCPDP SCRIPT
NCPDP SCRIPT Message Standard
U.S. e-prescription messaging standard required by Surescripts.
Surescripts
Surescripts Network Services
Medication history, real-time benefit check, and prior auth.
EPCS / DEA
DEA EPCS Regulations (21 CFR Part 1311)
Identity proofing, authentication, audit logging, and certification.
PDMP
PDMP & Interstate Data Exchange
State PDMP connectivity and interstate data sharing for monitoring.
EHR / Rx Systems
Prescribing Platforms We Integrate With
EHR and prescribing systems requiring Surescripts and EPCS.
Canada
Canadian Provincial Pharmacy Networks
Provincial systems providing prescription and dispensing data.
Prescriptions Should Reach the Pharmacy. Let's Build That Infrastructure.
Surescripts certification, EPCS, PDMP connectivity or Canadian provincial access — we build the pharmacy layer that routes prescriptions correctly.
Book a Pharmacy Consult
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Frequently Asked Questions
[ 1 ]
What is the NCPDP SCRIPT standard and who uses it?
NCPDP SCRIPT is the format for e-prescriptions between prescribing and pharmacy systems. Surescripts uses it for all routing, and every ePrescribing EHR implements it.
[ 2 ]
What are the DEA requirements for EPCS implementation?
EPCS (21 CFR Part 1311) requires DEA-approved identity proofing, two-factor signing, audit logging and access controls, plus a third-party audit before production.
[ 3 ]
How does PDMP integration work across state lines?
Each U.S. state runs its own PDMP. PMP InterConnect standardizes interstate sharing, so one integration retrieves multi-state controlled-substance history in one query.
[ 4 ]
How is ePrescribing handled in Canada differently from the United States?
Canada regulates ePrescribing province by province, with no national network. BC's PharmaNet, Alberta's NetRx and Ontario Health each differ — so serving Canada means separate work per province.
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